一、基本情况
许婷，中药学博士；校聘教授。主要从事天然产物的结构优化及其体内外抗菌活性及机制相关研究。在J. Med. Chem.（3篇，其中封面论文1篇，高被引2篇）， Eur. J. Med. Chem.， Ind. Crop. Prod.，Bioorg. Chem.，Biomed Pharmacother. 等国际主流学术期刊发表12篇SCI论文，其中中科院1区TOP 8篇。
Email: 18337173539@163.com
二、研究领域
1.天然药物化学：天然产物的结构优化及其体内外抗菌活性及机制相关研究
三、工作及学习经历
2025/11-至今，9428cn太阳集团古天乐，9428cn太阳集团古天乐，校聘教授
2023/10-2025/10，南华大学，9428cn太阳集团古天乐，团队博士后
2019/8-2023/8, 澳门科技大学，中药质量研究国家重点实验室，中药学博士
2016/9-2019/7, 郑州大学，9428cn太阳集团古天乐，生药学硕士
四、承担课题
1. 9428cn太阳集团古天乐博士后启动金，基于天然产物黄腐醇类化合物的结构优化、抗MRSA活性及机制研究（5524BH002），2024.01-2025.12，15万，主持。
2. 国家自然科学基金项目，青年项目，“细菌细胞膜损伤-DNA功能干扰”双机制丹参酮ⅡA类先导的发现及其抗耐甲氧西林金黄色葡萄球菌研究，82504623，2026.1.1—2028.12.31，30万，主持，在研;
3. 湖南省自然科学基金项目，青年项目，2025JJ60532，2025.1.1—2027.12.31，5万，主持，在研;
4. 湖南省教育厅项目，一般项目，丹参源:细菌细胞膜-DNA双靶向丹参酮ⅡA衍生物的发现及其抗菌活性研究，2324JY219，2025.1—2026.12，主持，1万，在研。
七、代表性文章
1) Xu, T., Xue, Z., Li, X., Zhang, M., Yang, R.*, Qin, S., Guo, Y*. Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties, J. Med. Chem., 2025, 68(7): 7459-7475.
2) Xu, T., Yan, X., Kang, A., et al. Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus (MRSA). J. Med. Chem., 2024, 67, 9302.
3) Xu T., Wang T., Tian Y, et al. An optimized 2, 2'-dipicolylamine-rutaecarpine quaternary ammonium derivative: targeting bacterial membrane disruption for enhanced anti-methicillin-resistant Staphylococcus aureus (MRSA) activity[J]. Eur. J. Med. Chem., 2025: 117975.
4) Cheng, W.#, Xu, T.#, Cui, L., et al. Development of Membrane-Targeting Fluorescent 2 Phenyl 1H phenanthro[9,10 d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus. Journal of Medicinal Chemistry, 2023, 66, 962−975
5）Xu, T., Tian, W., Guo Y.*, Bai, L. P*., et al. Novel 1, 3, 4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy. Bioorganic Chemistry, 2021, 115, 105257.
6）Xu T., Zheng Z., Guo Y.*, Bai L.-P.*. Semisynthesis of novel magnolol-based Mannich base derivatives that suppress cancer cells via inducing autophagy. European Journal of Medicinal Chemistry, 2020, 205, 112663.
7）Xu, T., Meng, J. R., Cheng, W., Liu, J. Z., Chu, J., Zhang, Q., Ma N., Bai L.-P. *, Guo, Y. *. Discovery of honokiol thioethers containing 1, 3, 4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors. Bioorganic & Medicinal Chemistry. 2022, 67, 116838.
8）Zheng Z. #, Xu T.#, Liu Z., Tian W., Jiang ZH., Zhu GY., Li T., Gao J., Bai L.-P.*. Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis. Biomed Pharmacother. 2022, 153, 113319.
9）Xu, T., Wang, X., Zhang, Q., … Guo, Y.* Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents. Bioorganic & Medicinal Chemistry Letters, 2018, 28(20), 3376-3380.
10) Zhang, F., Guo, Y.*, Xu, T.*, et al. A membrane-targeting magnololderivative for the treatment ofmethicillin-resistantStaphylococcus aureus infections. Front. Microbiol., 2024, 15:1385585.