一、基本情况
徐胜楠，博士，博士后。主要致力于探索植物源化合物的抗菌应用潜力，研究方向聚焦于现代医学与农业领域。近五年在ACS Infect. Dis，J. Med. Chem，Physiol. Plant等高水平杂志发表研究论文7篇，参编专著1部，参与陕西省重点研发项目一项。
Email: 18317898327@163.com
二、研究领域
1. 天然产物抗菌机制的探索
致力于揭示天然产物，特别是植物源化合物的抗菌作用机理，从分子与细胞水平阐明其抑菌或杀菌的通路与靶点。
2. 植物源抗菌化合物的发现与开发
专注于从植物资源中发现与鉴定具有抗菌活性的先导化合物，并评估其在医药与农业领域的应用潜力。
三、工作及学习经历
2025/11-至今，9428cn太阳集团古天乐，9428cn太阳集团古天乐，校聘副教授
2023/11-2025/11，9428cn太阳集团古天乐，9428cn太阳集团古天乐，博士后
2019/9-2023/6，西北农林科技大学，林公司，博士
2016/9-2019/6，郑州大学，9428cn太阳集团古天乐，硕士
2012/9-2016/6，河南大学，9428cn太阳集团古天乐，学士
四、代表性文章
1) Xu, S#., Zhang, M#., Xie, X#., Tian, Y., Wang, Y., Wang, X., Yang, R*., & Guo, Y*. Discovery of novel xanthotoxin-pyridine quaternary ammonium derivatives with membrane-targeting mode of action as potential antimicrobials against methicillin-resistant Staphylococcus aureus. Eur. J. Med. Chem., 2025, 118139.
2) Xu, S., Kang, A., Tian, Y., Li, X., Qin, S., Yang, R*., & Guo, Y*. Plant flavonoids with antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), ACS Infect. Dis., 2024, 10(9): 3086-3097.
3) Yang, R#., Cui, L#., Xu, S., Zhong, Y., Xu, T., Liu, J., Lan, Z., Qin, S., & Guo, Y*. Membrane-targeting amphiphilic honokiol derivatives containing an oxazole moiety as potential antibacterials against methicillin-resistant Staphylococcus aureus. J. Med. Chem., 2024, 67(18), 16858-16872.
4) Xu, S., Hu, H., Wang, Z., Yang, Z., Wei, X., & Li, D*. Integrated transcriptome and metabolome analysis reveals the podophyllotoxins accumulation and formation mechanisms in Juniperus sabina L. leaves, Physiol. Plant. 2024, 176(1), e14176.
5) Xu, S., Chen, Q., Luo, N., Yang, J., & Li, D*. Effects of age and tissue of Juniperus sabina L. on its phytochemical characteristics, anti-cholinesterase, antidiabetes, and anti-drug resistant bacteria activities, Front. Plant Sci. 2023, 14(1).
6) Xu, S., Yu, L., Hou, Y., Huang, B., Wang, H., Li, D*., & Wang, D*. Chemical composition, chemotypic characterization, and histochemical localization of volatile components in different cultivars of Zanthoxylum bungeanum Maxim. Leaves, J. Food Sci. 2023, 88(4), 1336-1348.
7) Xu, S., Li, X., Liu, S., Tian, P., & Li, D*. Juniperus sabina L. as a source of podophyllotoxins: extraction optimization and anticholinesterase activities, Int. J. Mol. Sci. 2022, 23(18), 10205.